KPNA2 Antibody, HRP conjugated - Cat. #: CSB-PA012484LB01HU

SKU: CSB-PA012484LB01HU

Size :50ug

Clone Number:

Aliases:IMA1_HUMAN antibody; Importin alpha 1 antibody; Importin alpha 2 antibody; Importin alpha 2 subunit antibody; Importin alpha P1 antibody; Importin subunit alpha-1 antibody; IPO A1 antibody; IPOA 1 antibody; IPOA1 antibody; Karyopherin alpha 2 antibody; Karyopherin alpha 2 RAG cohort 1 antibody; Karyopherin alpha 2 subunit antibody; Karyopherin subunit alpha-2 antibody; KPNA2 antibody; KPNA2 protein antibody; Pendulin antibody; QIP 2 antibody; QIP2 antibody; RAG cohort 1 antibody; RAG cohort protein 1 antibody; RCH 1 antibody; RCH1 antibody; SRP 1 antibody; SRP1 alpha antibody; SRP1 antibody; SRP1-alpha antibody; SRP1alpha antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P52292

Immunogen:Recombinant Human Importin subunit alpha-1 protein (2-285AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KPNA2

Research Areas:Immunology; Signal transduction