(KO Validated) DNMT1 Polyclonal Antibody

SKU: E-AB-60994

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:DNMT1

Target Synonym:ADCADN;AIM;CXXC9;DNMT;HSN1E;MCMT;m.HsaI;DNMT1

Research Areas:Cancer;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IF

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P26358

Accession:

Background:This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Concentration:1mg/mL

Immunogen:Recombinant fusion protein of human DNMT1 (NP_001370.1).

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification method:Affinity purification

Dilution:WB 1:500-1:2000;IF 1:50-1:200

Calculated MW:144kDa/183kDa/184kDa

ObservedMW:200kDa