KMT5A Antibody, HRP conjugated - Cat. #: CSB-PA889082LB01HU

SKU: CSB-PA889082LB01HU

Size :50ug

Clone Number:

Aliases:H4 K20 HMTase antibody; H4 K20 specific histone methyltransferase antibody; H4-K20-HMTase SETD8 antibody; Histone H4 K20 methyltransferase antibody; Histone lysine N methyltransferase H4 lysine 20 specific antibody; Histone-lysine N-methyltransferase SETD8 antibody; Lysine N-methyltransferase 5A antibody; N-lysine methyltransferase SETD8 antibody; Pr SET 7 antibody; Pr SET7 antibody; PR-Set7 antibody; PR/SET domain containing protein 07 antibody; PR/SET domain containing protein 8 antibody; PR/SET domain-containing protein 07 antibody; PR/SET07 antibody; PrSET7 antibody; SET 07 antibody; SET 8 antibody; SET domain containing (lysine methyltransferase) 8 antibody; SET domain containing 8 antibody; SET domain containing lysine methyltransferase 8 antibody; SET domain containing protein 8 antibody; SET domain-containing protein 8 antibody; SET07 antibody; SET8 antibody; SETD 8 antibody; setd8 antibody; SETD8_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NQR1

Immunogen:Recombinant Human N-lysine methyltransferase KMT5A protein (136-258AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates \\\'Lys-20\\\' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at \\\'Lys-382\\\', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KMT5A

Research Areas:Epigenetics and Nuclear Signaling