KIR3DL1 Polyclonal Antibody

SKU: E-AB-19041

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: KIR3DL1

Target Synonym: AMB11;CD158 antigen-like family member E;CD158e;CD158e antigen;CD158E1;CD158E1/2;CD158E2;CL11;CL2;HLA-BW4-specific inhibitory NK cell receptor;KI3L1;killer cell immunoglobulin like receptor;Killer cell immunoglobulin like receptor three domains;short cytoplasmic tail;1;Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1;Killer cell immunoglobulin-like receptor 3DL1;KIR;KIR antigen 3DL1;KIR G1;Kir3dl1;KIR3DS1;Kirl1;Kirl2;Krl1;MGC119726;MGC119728;MGC126589;MGC126591;MHC class I NK cell receptor;Natural killer associated transcript 3;Natural killer cell inhibitory receptor;Natural killer-associated transcript 3;NK receptor;NK-associated transcript 10;NK-associated transcript 3;NK-associated transcript 3delIg1;NKAT-3;NKAT10;NKAT3;NKB1;NKB1B;p70 killer cell inhibitory receptor;p70 natural killer cell receptor clones CL 2/CL 11;p70 natural killer cell receptor clones CL-2/CL-11;p70 NK receptor CL-2/CL-11

Research Areas: Immunology

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P43629

Accession:

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Concentration: 1.68 mg/mL

Immunogen: Fusion protein of human KIR3DL1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:50-1:300

Calculated MW:

ObservedMW: