KEAP1 Antibody, Biotin conjugated - Cat. #: CSB-PA012147LD01HU

SKU: CSB-PA012147LD01HU

Size :50ug

Clone Number:

Aliases:Cytosolic inhibitor of Nrf2 antibody; INrf 2 antibody; INrf2 antibody; Keap 1 antibody; KEAP1 antibody; KEAP1_HUMAN antibody; Kelch like ECH associated protein 1 antibody; Kelch like family member 19 antibody; Kelch like protein 19 antibody; Kelch-like ECH-associated protein 1 antibody; Kelch-like protein 19 antibody; KIAA0132 antibody; KLHL 19 antibody; KLHL19 antibody; MGC10630 antibody; MGC1114 antibody; MGC20887 antibody; MGC4407 antibody; MGC9454 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q14145

Immunogen:Recombinant Human Kelch-like ECH-associated protein 1 protein (1-624AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KEAP1

Research Areas:Epigenetics and Nuclear Signaling