KCNQ1 Monoclonal Antibody

SKU: BT-MCA4240

Size:100μL

Background:This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Research_area:Cardiovascular, Metabolism, Neuroscience, Signal transduction

Target_protein:KCNQ1

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:5E12

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:KCNQ1

Immunogen:Purified recombinant fragment of human KCNQ1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):95kDa

UniProt accession:P51787

Synonyms:LQT, RWS, WRS, LQT1, SQT2, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, Kv1.9, Kv7.1, KVLQT1, FLJ26167

GeneID:3784