KCNMB1 Antibody, Biotin conjugated - Cat. #: CSB-PA621958LD01HU

SKU: CSB-PA621958LD01HU

Size :50ug

Clone Number:

Aliases:BK channel beta subunit antibody; BK channel subunit beta 1 antibody; BK channel subunit beta-1 antibody; BKbeta antibody; BKbeta1 antibody; Calcium activated potassium channel subfamily M subunit beta 1 antibody; Calcium activated potassium channel subunit beta 1 antibody; Calcium activated potassium channel subunit beta antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta antibody; Calcium-activated potassium channel subunit beta-1 antibody; Charybdotoxin receptor subunit beta 1 antibody; Charybdotoxin receptor subunit beta-1 antibody; Hbeta1 antibody; hslo beta antibody; K(VCA)beta 1 antibody; K(VCA)beta antibody; K(VCA)beta-1 antibody; KCMB1_HUMAN antibody; KCNMB 1 antibody; Kcnmb1 antibody; Large conductance Ca2+ activated K+ channel beta 1 subunit antibody; Maxi K channel beta subunit antibody; Maxi K channel subunit beta 1 antibody; Maxi K channel subunit beta-1 antibody; Potassium large conductance calcium activated channel subfamily M beta member 1 antibody; Slo beta 1 antibody; SLO beta antibody; Slo-beta antibody; Slo-beta-1 antibody; subfamily M subunit beta-1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q16558

Immunogen:Recombinant Human Calcium-activated potassium channel subunit beta-1 protein (40-130AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KCNMB1

Research Areas:Neuroscience; Cardiovascular; Metabolism; Signal transduction