KCNC3 Antibody, Biotin conjugated - Cat. #: CSB-PA621758LD01HU

SKU: CSB-PA621758LD01HU

Size :50ug

Clone Number:

Aliases:Kcnc3 antibody; KCNC3_HUMAN antibody; KSHIIID antibody; KV3.3 antibody; Potassium voltage gated channel Shaw related subfamily member 3 antibody; Potassium voltage gated channel subfamily C member 3 antibody; Potassium voltage-gated channel subfamily C member 3 antibody; SCA13 antibody; Shaw related subfamily, member 3 antibody; Shaw related voltage gated potassium channel protein 3 antibody; Spinocerebellar ataxia 13 antibody; Voltage gated potassium channel protein KV3.3 antibody; Voltage gated potassium channel subunit Kv3.3 antibody; Voltage-gated potassium channel subunit Kv3.3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q14003

Immunogen:Recombinant Human Potassium voltage-gated channel subfamily C member 3 protein (638-745AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KCNC3

Research Areas:Neuroscience