JNK3 Rabbit Polyclonal Antibody

SKU: BT-AP10588

Size:100μL

Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Research_area:Cancer; Neuroscience; Signal transduction

Target_protein:MAPK10

applications:IHC-p, IF

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Mitogen-activated protein kinase 10

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P53779; Mouse: Q61831; Rat: P49187

Synonyms:Mitogen-activated protein kinase 10 ;MAP kinase 10;MAPK 10;EC 2.7.11.24;MAP kinase p49 3F12;Stress-activated protein kinase 1b;SAPK1b;Stress-activated protein kinase JNK3;c-Jun N-termina; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; EC 2.7.11.24; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3

GeneID:Human: 5602