JAM3 Monoclonal Antibody

SKU: BT-MCA3369

Size:100μL

Background:Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.

Research_area:Cardiovascular, Signal transduction, Tags & cell markers

Target_protein:JAM3

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2A5B6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:JAM3

Immunogen:Purified recombinant fragment of human JAM3 (AA: extra 32-241) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):35kDa

UniProt accession:Q9BX67

Synonyms:JAMC, JAM-2, JAM-3, JAM-C

GeneID:83700