ISCU Antibody - Cat. #: CSB-PA887955ESR2HU

SKU: CSB-PA887955ESR2HU

Size :50ul

Clone Number:

Aliases:2310020H20Rik antibody; HML antibody; hnifU antibody; Iron sulfur cluster assembly enzyme ISCU mitochondrial antibody; Iron sulfur cluster scaffold homolog (E. coli) antibody; Iron sulfur cluster scaffold homolog antibody; Iron-sulfur cluster assembly enzyme ISCU antibody; Iscu antibody; IscU iron sulfur cluster scaffold homolog antibody; ISCU_HUMAN antibody; ISU2 antibody; MGC74517 antibody; mitochondrial antibody; NIFU antibody; NifU like N terminal domain containing antibody; NifU like N terminal domain containing protein antibody; NifU like protein antibody; NifU-like N-terminal domain-containing protein antibody; NifU-like protein antibody; NIFUN antibody; Nitrogen fixation cluster like antibody; OTTHUMP00000238760 antibody; OTTHUMP00000238761 antibody; OTTHUMP00000238762 antibody; OTTHUMP00000238764 antibody; OTTHUMP00000238765 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H1K1

Immunogen:Recombinant Human Iron-sulfur cluster assembly enzyme ISCU, mitochondrial protein (1-167AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ISCU

Research Areas:Metabolism; Signal transduction