IMPA1 Polyclonal Antibody

SKU: E-AB-18668

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: IMPA1

Target Synonym: IMP 1;IMP;IMPA 1;IMPA;IMPA1;IMPA1;IMPase 1;IMPase;Inositol 1(or 4) monophosphatase;Inositol monophosphatase 1;Inositol monophosphatase;Inositol(myo) 1(or 4) monophosphatase 1;Inositol-1(or 4)-monophosphatase 1;Lithium sensitive myo inositol monophosphatase A1;Lithium-sensitive myo-inositol monophosphatase A1

Research Areas: Cancer;Metabolism;Neuroscience;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P29218

Accession:

Background: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Concentration: 0.9 mg/mL

Immunogen: Fusion protein of human IMPA1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:500-1:2000;IHC 1:25-1:100

Calculated MW: 30 kDa

ObservedMW: Refer to figures