IGF1R-Beta Monoclonal Antibody

SKU: BT-MCA4332

Size:100μL

Background:IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

Research_area:Others

Target_protein:IGF1R-Beta

applications:IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:3C8B1

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:IGF1R-Beta

Immunogen:Purified recombinant fragment of IGF1R-Beta expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):96kDa

UniProt accession:P08069

Synonyms:IGF1R, IGF1R-Beta

GeneID:3480