IDE/Insulin Degrading Enzyme Mouse mAb

SKU: EM1083

Size: 100μL

Source:Mouse

Applications:WB, IHC

Reactivity:Human

Dilution:WB 1:1,000 IHC 1:200

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):118kDa

Human_gene_id:3416

Human_swiss_prot_no:P14735

Subcellular_location:Cell membrane, Cytoplasm, Membrane, Secreted

Other_name:Abeta degrading protease, insulin degrading enzyme, Insulin protease, Insulinase, INSULYSIN

Background:Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently.