Human Zinc Finger Protein Gli1, GLI1 ELISA Kit

SKU: E6417Hu

Size:96 Tests-1 Kit

Background:Acts as a transcriptional activator (PubMed: 19706761, PubMed: 10806483, PubMed: 19878745, PubMed: 24311597, PubMed: 24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed: 2105456, PubMed: 8378770, PubMed: 24217340). Regulates the transcription of specific genes during normal development (PubMed: 19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed: 19706761, PubMed: 28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed: 11238441, PubMed: 28973407). [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.

Research_area:Others

Applications:ELISA

Target_protein:GLI1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.85ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Zinc Finger Protein GLI1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08151

MASS(Da):117,904

GeneID:2735

Synonyms:GLI 1;GLI1;Glioma-associated oncogene;Oncogene GLI;Zinc finger protein GLI1

Gene names:GLI1

Standard solution:3200ng/L