Human Vesicle-associated Membrane Protein 8, VAMP8 ELISA Kit

SKU: E6396Hu

Size:96 Tests-1 Kit

Background:SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946).

Research_area:Neuroscience; Immunology

Applications:ELISA

Target_protein:VAMP8

Reactivity:Human

Assay type:Sandwich

Sensitivity:8.96ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Vesicle-associated membrane protein 8

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BV40

MASS(Da):11,438

GeneID:8673

Synonyms:EDB;Endobrevin;VAMP8;VAMP-8;Vesicle-associated membrane protein 8

Gene names:VAMP8

Standard solution:8000ng/L