Human Ubiquitin fusion degradation protein 1,UFD1L ELISA KIT

SKU: E6373Hu

Size:96 Tests-1 Kit

Background:Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}.

Research_area:

Applications:ELISA

Target_protein:UFD1

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.02ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ubiquitin fusion degradation protein 1 homolog

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92890

MASS(Da):34500

GeneID:7353

Synonyms:UFD1 UFD1L

Gene names:UFD1

Standard solution:9600ng/L