Human Ubiquilin 2, UBQLN2 ELISA Kit

SKU: E2612Hu

Size:96 Tests-1 Kit

Background:Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed: 10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed: 24215460, PubMed: 18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed: 19148225, PubMed: 20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed: 18199683).

Research_area:Cell Biology

Applications:ELISA

Target_protein:UBQLN2

Reactivity:Human

Assay type:Sandwich

Sensitivity:25.26ng/L

Detection range:50-10000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ubiquilin 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UHD9

MASS(Da):65,696

GeneID:29978

Synonyms:Chap1;DSK2 homolog;hPLIC-2;PLIC-2;Protein linking IAP with cytoskeleton 2;Ubiquilin-2;Ubiquitin-like product Chap1/Dsk2;UBQLN 2;UBQLN2;

Gene names:UBQLN2

Standard solution:12800ng/L