Human Tyrosine Protein Phosphate Non-receptor Type 22, PTPN22 ELISA Kit

SKU: E3436Hu

Size:96 Tests-1 Kit

Background:Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed: 16461343, PubMed: 18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed: 21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed: 16461343). Dephosphorylates the immune system activator SKAP2 (PubMed: 21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed: 23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed: 23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:PTPN22

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine Protein Phosphate Non-Receptor Type 22

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y2R2

MASS(Da):91,705

GeneID:26191

Synonyms:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP;Lymphoid phosphatase;LyP;PEP;PEST-domain phosphatase;PTPN 22;PTPN22;Tyrosine-protein phosphatase non-receptor type 22

Gene names:PTPN22

Standard solution:32ng/ml