Human Tumor Susceptibility Gene 101 Protein, TSG101 ELISA Kit

SKU: E6353Hu

Size:96 Tests-1 Kit

Background:Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed: 22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed: 22315426).

Research_area:Cancer

Applications:ELISA

Target_protein:TSG101

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.86ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tumor Susceptibility Gene 101 Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99816

MASS(Da):43,944

GeneID:7251

Synonyms:ESCRT-I complex subunit TSG101;TSG 101;TSG101;Tumor susceptibility gene 101 protein

Gene names:TSG101

Standard solution:3200ng/L