Human TRANCE/RANKL/TNFSF11 PicoKine® Quick ELISA Kit

SKU: FEK0842

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFSF11

Specificity: Natural and recombinant Human TNFSF11

Background: Receptor activator of nuclear factor kappa-B ligand(RANKL), also known as tumor necrosis factor ligand superfamily member 11(TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor(TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This gene is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Immunogen: Expression system for standard: NS0; Immunogen sequence: G64-D245

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Reference:

Uniprot ID: O14788

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 8600

Protein Name: Tumor necrosis factor ligand superfamily member 11

Gene Full Name: TNF superfamily member 11

Synonyms: CD254; hRANKL2; ODF; OPGL; OPTB2; Osteoprotegerin ligand; RANKL; sOdf; TNFSF11; TRANCE