Human Toll-like Receptor 5, TLR5 ELISA Kit

SKU: E0374Hu

Size:96 Tests-1 Kit

Background:Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed: 11323673, PubMed: 18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed: 29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed: 20855887, PubMed: 11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).

Research_area:Immunology

Applications:ELISA

Target_protein:TLR5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.05ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Toll-Like Receptor 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O60602

MASS(Da):97,834

GeneID:7100

Synonyms:TLR 5;TLR5;Toll/interleukin-1 receptor-like protein 3;Toll-like receptor 5

Gene names:TLR5

Standard solution:48ng/ml