Human TNFSF4/OX40L ELISA Kit PicoKine®

SKU: EK0857

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFSF4

Specificity: Natural and recombinant human TNFSF4

Background: OX40L is the ligand for CD134 and is expressed on such cells as DC2s enabling amplification of Th2 cell differentiation. OX40L has also been designated CD252. By analysis of an interspecific backcross, the mouse Tnfsf4 gene is mapped to chromosome 1. Using fluorescence in situ hybridization, they localized the human TNFSF4 gene to 1q25, a region sharing homology of synteny with the portion of mouse chromosome 1 containing the Tnfsf4 gene. OX40L strongly inhibited the generation of IL-10-producing Tr1 cells induced by two physiologic stimuli, the inducible costimulatory ligand and immature dendritic cells. In addition, OX40L strongly inhibited IL-10 production and suppressive function of differentiated IL-10-producing Tr1 cells. Tnfsf4 underlies Ath1 in mice and that polymorphisms in its human homolog TNFSF4 increase the risk of myocardial infarction in humans.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q51-L183

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Uniprot ID: P23510

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 7292

Protein Name: Tumor necrosis factor ligand superfamily member 4

Gene Full Name: TNF superfamily member 4

Synonyms: GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40L