Human T-lymphocyte Activation Antigen Cd86, CD86 ELISA Kit

SKU: E1572Hu

Size:96 Tests-1 Kit

Background:Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed: 7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Research_area:Immunology

Applications:ELISA

Target_protein:CD86

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.05ng/ml

Detection range:0.1-40.ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:T-Lymphocyte Activation Antigen CD86

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P42081

MASS(Da):37,682

GeneID:942

Synonyms:Activation B7-2 antigen;B70;BU63;CD 86;CD antigen CD86;CD86;CTLA-4 counter-receptor B7.2;FUN-1;T-lymphocyte activation antigen CD86;

Gene names:CD86

Standard solution:48ng/ml