Human Spry Domain-containing Socs Box Protein 4, SPSB4 ELISA Kit

SKU: E3181Hu

Size:96 Tests-1 Kit

Background:Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).

Research_area:Cell Biology; Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:SPSB4

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.32ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:SPRY domain-containing SOCS box protein 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96A44

MASS(Da):30,179

GeneID:92369

Synonyms:SPRY domain-containing SOCS box protein 4;SPSB4;SSB4;SSB-4

Gene names:SPSB4

Standard solution:1600ng/L