Human Spry Domain-containing Socs Box Protein 2, SPSB2 ELISA Kit

SKU: E3179Hu

Size:96 Tests-1 Kit

Background:Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).

Research_area:Cell Biology

Applications:ELISA

Target_protein:SPSB2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.12ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:SPRY domain-containing SOCS box protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99619

MASS(Da):28,630

GeneID:84727

Synonyms:Gene-rich cluster protein C9;GRCC9;SPRY domain-containing SOCS box protein 2;SPSB2;SSB2;SSB-2

Gene names:SPSB2

Standard solution:2400ng/L