Human Spry Domain-containing Socs Box Protein 1, SPSB1 ELISA Kit

SKU: E3178Hu

Size:96 Tests-1 Kit

Background:Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 15601820, PubMed: 21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed: 21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed: 21199876).

Research_area:Others

Applications:ELISA

Target_protein:SPSB1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.96ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Spry Domain-Containing Socs Box Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96BD6

MASS(Da):30,942

GeneID:80176

Synonyms:SPRY domain-containing SOCS box protein 1;SPSB 1;SPSB1;SSB-1

Gene names:SPSB1

Standard solution:4800ng/L