Human Sorting Nexin 2, SNX2 ELISA Kit

SKU: E2548Hu

Size:96 Tests-1 Kit

Background:Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed: 16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed: 17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed: 23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed: 20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed: 20604901).

Research_area:Others

Applications:ELISA

Target_protein:SNX2

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.14ng/L

Detection range:25-5000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sorting Nexin 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O60749

MASS(Da):58,471

GeneID:6643

Synonyms:SNX 2;SNX2;Sorting nexin-2;Transformation-related gene 9 protein;TRG-9

Gene names:SNX2

Standard solution:5600ng/L