Human soluble Interleukin-1 receptor type 2,sIL1R2 ELISA KIT

SKU: E0207Hu

Size:96 Tests-1 Kit

Background:Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.

Research_area:

Applications:ELISA

Target_protein:IL1R2

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.08ng/ml

Detection range:2-600ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:soluble interleukin-1 receptor 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P27930

MASS(Da):45421

GeneID:7850

Synonyms:IL1R2 IL1RB

Gene names:IL1R2

Standard solution:800ng/ml