Human soluble CD5 ELISA Kit PicoKine®

SKU: EK1220

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CD5

Specificity: Natural and recombinant human CD5

Background: CD5, also known as T1 or LEU1, is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. It is mapped to 11q12.2. Although CD5 can be found on both T cells and B cells, T cells express higher levels of CD5 than B cells. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides. Nevertheless, CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins.

Immunogen: Expression system for standard: NS0; Immunogen sequence: R25-N371

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Reference:

Uniprot ID: P06127

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 921

Protein Name: T-cell surface glycoprotein CD5

Gene Full Name: CD5 molecule

Synonyms: CD5; CD5 molecule; LEU1; Lymphocyte antigen T1/Leu 1; T1