Human Sialidase-3, NEU3 ELISA Kit

SKU: E3140Hu

Size:96 Tests-1 Kit

Background:Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452).

Research_area:Others

Applications:ELISA

Target_protein:NEU3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.017ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sialidase-3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UQ49

MASS(Da):48,252

GeneID:10825

Synonyms:Ganglioside sialidasedis;Membrane sialidase;N-acetyl-alpha-neuraminidase 3;NEU3;SIAL3;Sialidase-3

Gene names:NEU3

Standard solution:16ng/ml