Human Sialidase-2, NEU2 ELISA Kit

SKU: E3139Hu

Size:96 Tests-1 Kit

Background:Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed: 14613940, PubMed: 22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed: 14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homopolymer of alpha-(2->8)-linked Neu5Ac residues (PubMed: 14613940).

Research_area:Others

Applications:ELISA

Target_protein:NEU2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sialidase-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y3R4

MASS(Da):42,254

GeneID:4759

Synonyms:Cytosolic sialidase;N-acetyl-alpha-neuraminidase 2;NEU 2;NEU2;Sialidase-2

Gene names:NEU2

Standard solution:32ng/ml