Human SH3 Domain Containing GRB2 Like Endophilin B1,SH3GLB1 ELISA KIT

SKU: E7369Hu

Size:96 Tests-1 Kit

Background:May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144, ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21068542}.

Research_area:

Applications:ELISA

Target_protein:SH3GLB1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.16ng/ml

Detection range:0.3-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:SH3 Domain Containing GRB2 Like Endophilin B1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y371

MASS(Da):40796

GeneID:51100

Synonyms:SH3GLB1 KIAA0491 CGI-61

Gene names:SH3GLB1

Standard solution:96ng/ml