Human Reversion-inducing Cysteine-rich Protein with Kazal Motifs, RECK ELISA Kit

SKU: E4359hu

Size:96 Tests-1 Kit

Background:Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed: 28289266, PubMed: 30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed: 30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed: 30026314). Also acts as a serine protease inhibitor: negatively regulates Matrix Metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed: 9789069, PubMed: 18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed: 9789069).

Research_area:Others

Applications:ELISA

Target_protein:RECK

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.052ng/ml

Detection range:0.1-35ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95980

MASS(Da):106,457

GeneID:8434

Synonyms:hRECK;RECK;Reversion-inducing cysteine-rich protein with Kazal motifs;Suppressor of tumorigenicity 15 protein

Gene names:RECK

Standard solution:40ng/ml