Human Renin / Prorenin ELISA Kit PicoKine®

SKU: EK1249

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: REN

Specificity: Natural and recombinant human Renin

Background: Renin, also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin system (RAS). This gene is mapped to 1q32.1. Renin's primary function is to cause an increase in blood pressure, leading to restoration of perfusion pressure in the kidneys. It also can catalyze the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. What's more, Renin secretion is also stimulated by sympathetic nervous stimulation, mainly through beta-1 adrenoceptor activation.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L67-R406

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Uniprot ID: P00797

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 5972

Protein Name: Renin

Gene Full Name: renin

Synonyms: Angiotensinogenase; REN; Renin