Human Proto-oncogene c-Fos,fos ELISA KIT

SKU: E0614Hu

Size:96 Tests-1 Kit

Background:Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.

Research_area:

Applications:ELISA

Target_protein:FOS

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.21ng/L

Detection range:10-4000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Proto-oncogene c-Fos

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01100

MASS(Da):40695

GeneID:2353

Synonyms:FOS G0S7

Gene names:FOS

Standard solution:4000ng/L