Human Proteasome Subunit Beta Type 6, PSMB6 ELISA Kit

SKU: E2427Hu

Size:96 Tests-1 Kit

Background:Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic Peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the Peptides bond hydrolysis occurs directly after acidic residues.

Research_area:Others

Applications:ELISA

Target_protein:PSMB6

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.98ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Proteasome Subunit Beta Type 6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P28072

MASS(Da):25,358

GeneID:5694

Synonyms:Macropain delta chain;Multicatalytic endopeptidase complex delta chain;Proteasome delta chain;Proteasome subunit beta type-6;Proteasome subunit Y;PSMB 6;PSMB6

Gene names:PSMB6

Standard solution:1600ng/L