Human Prostaglandin E Synthase 3, PTGES3 ELISA Kit

SKU: E5941Hu

Size:96 Tests-1 Kit

Background:Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed: 18682561, PubMed: 10377395, PubMed: 12672824, PubMed: 12460774, PubMed: 10869354, PubMed: 12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed: 12244105, PubMed: 12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed: 12672824).

Research_area:Others

Applications:ELISA

Target_protein:PTGES

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.47ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Prostaglandin E Synthase 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14684

MASS(Da):17,102

GeneID:9536

Synonyms:Glutathione peroxidase PTGES;Glutathione transferase PTGES;MGST1-L1;Microsomal glutathione S-transferase 1-like 1;Microsomal prostaglandin E Synthase 1;MPGES-1;p53-induced gene 12 protein;Prostaglandin E Synthase;PTGES;

Gene names:PTGES

Standard solution:4800ng/L