Human Probable lysosomal cobalamin transporter,LMBRD1 ELISA KIT

SKU: E5911Hu

Size:96 Tests-1 Kit

Background:Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed:27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K0B2, ECO:0000269|PubMed:19136951, ECO:0000269|PubMed:27456980, ECO:0000303|PubMed:25535791}.; [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). {ECO:0000269|PubMed:15956556}.

Research_area:

Applications:ELISA

Target_protein:LMBRD1

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.25ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Probable lysosomal cobalamin transporter

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NUN5

MASS(Da):61389

GeneID:55788

Synonyms:LMBRD1 C6orf209 NESI BM-021 CD001 MSTP044

Gene names:LMBRD1

Standard solution:1600ng/L