Human Pro-nerve Growth Factor, PRONGF ELISA Kit

SKU: E5936Hu

Size:96 Tests-1 Kit

Background:Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed: 14976160, PubMed: 20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed: 20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed: 20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:NGF

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Pro-Nerve Growth Factor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01138

MASS(Da):26,959

GeneID:4803

Synonyms:Beta-nerve growth factor;Beta-NGF;NGF

Gene names:NGF

Standard solution:24ng/mL