Human Potassium Channel Subfamily K Member 18, KCNK18 ELISA Kit

SKU: E1789Hu

Size:96 Tests-1 Kit

Background:Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:KCNK18

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Potassium Channel subfamily K member 18

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q7Z418

MASS(Da):43,671

GeneID:338567

Synonyms:K2p18.1;KCNK18;MGR13;Potassium Channel subfamily K member 18;TRESK;TRESK2;TRESK-2;TRIK;TWIK-related individual potassium Channel;TWIK-related spinal cord potassium Channel

Gene names:KCNK18

Standard solution:12.8ng/ml