Human PLAT/TPA ELISA Kit PicoKine®

SKU: EK0897

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: PLAT

Specificity: Natural and recombinant human PLAT

Background: Plasminogen activator, tissue, also called PLAT or TPA is a serine protease. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This gene was mapped to 8p11.21. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

Immunogen: Expression system for standard: CHO; Immunogen sequence: M1-P562

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Reference:

Uniprot ID: P00750

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 5327

Protein Name: Tissue-type plasminogen activator

Gene Full Name: plasminogen activator, tissue type

Synonyms: Alteplase; plasminogen activator; tissue; PLAT; Reteplase; T PA; t plasminogen activator; Tissue Plasminogen Activator; tPA