Human P16 Monoclonal Antibody

SKU: BT-MCA3472

Size:100μL

Background:p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

Research_area:Others

Target_protein:Human P16

applications:IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:5A8A4; 3G8D12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:Human P16

Immunogen:Purified recombinant fragment of P16 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P42771

Synonyms:Human P16

GeneID:1029