Human osteoclast differentiation factor,ODF ELISA KIT

SKU: E0158Hu

Size:96 Tests-1 Kit

Background:Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). {ECO:0000250|UniProtKB:O35235, ECO:0000269|PubMed:22664871}.

Research_area:

Applications:ELISA

Target_protein:TNFSF11

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.52ng/ml

Detection range:1-400ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:osteoclast differentiation factor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14788

MASS(Da):35478

GeneID:8600

Synonyms:TNFSF11 OPGL RANKL TRANCE

Gene names:TNFSF11

Standard solution:480ng/ml