Human NQO1 ELISA Kit PicoKine®

SKU: EK2277

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: NQO1

Specificity: Natural and recombinant human NQO1

Background: NAD(P)H dehydrogenase [quinone] 1 is an enzyme that in humans is encoded by the NQO1 gene. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: M1-K274

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Reference:

Uniprot ID: P15559

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1728

Protein Name: NAD

Gene Full Name: NAD(P)H quinone dehydrogenase 1

Synonyms: Azoreductase; DHQU; DIA4; DT diaphorase; DTD; Menadione reductase; NQO1; Phylloquinone reductase; QR1; Quinone reductase 1