Human Neurogenic Locus Notch Homolog Protein 2, NOTCH2 ELISA Kit

SKU: E3262Hu

Size:96 Tests-1 Kit

Background:Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed: 21378985, PubMed: 21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed: 29149593). Positively regulates self-renewal of liver cancer cells (PubMed: 25985737).

Research_area:Others

Applications:ELISA

Target_protein:NOTCH2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.26ng/ml

Detection range:0.5-100ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neurogenic Locus Notch Homolog Protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q04721

MASS(Da):265,405

GeneID:4853

Synonyms:hN2;N2ECD;N2ICD;Neurogenic locus notch homolog protein 2;NOTCH 2;Notch 2 extracellular truncation;Notch 2 intracellular domain;NOTCH2

Gene names:NOTCH2

Standard solution:128ng/ml