Human Nesprin-1, SYNE1 ELISA Kit

SKU: E5747Hu

Size:96 Tests-1 Kit

Background:Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:SYNE1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.33ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nesprin-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8NF91

MASS(Da):1,011,086

GeneID:23345

Synonyms:Enaptin;KASH domain-containing protein 1;KASH1;Myne-1;Myocyte nuclear envelope protein 1;Nesprin-1;Nuclear envelope spectrin repeat protein 1;Synaptic nuclear envelope protein 1;SYNE 1;SYNE1;Syne-1

Gene names:SYNE1

Standard solution:4800ng/L