Human Myocilin, MYOC ELISA Kit

SKU: E2943Hu

Size:96 Tests-1 Kit

Background:Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.

Research_area:Others

Applications:ELISA

Target_protein:MYOC

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024U/mL

Detection range:0.05-20U/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Myocilin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99972

MASS(Da):56,972

GeneID:4653

Synonyms:MYOC;Myocilin;Myocilin 20 kDa N-terminal fragment;Myocilin 35 kDa N-terminal fragment;Myocilin 55 kDa subunit;Myocilin, C-terminal fragment;Myocilin, N-terminal fragment;Trabecular meshwork-induced glucocorticoid response protein

Gene names:MYOC

Standard solution:24U/mL