Human Multidrug Resistance-associated Protein 1, ABCC1 ELISA Kit

SKU: E5702Hu

Size:96 Tests-1 Kit

Background:Mediates export of organic anions and drugs from the cytoplasm (PubMed: 7961706, PubMed: 16230346, PubMed: 9281595, PubMed: 10064732, PubMed: 11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed: 7961706, PubMed: 16230346, PubMed: 9281595, PubMed: 10064732, PubMed: 11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed: 9281595). Hydrolyzes ATP with low efficiency (PubMed: 16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed: 17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:ABCC1

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.34ng/mL

Detection range:10-2000ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Multidrug Resistance-Associated Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P33527

MASS(Da):171,591

GeneID:4363

Synonyms:ABCC 1;ABCC1;ATP-binding cassette sub-family C member 1;Glutathione-S-conjugate-translocating ATPase ABCC1;Leukotriene C(4 transporter;LTC4 transporter;Multidrug resistance-associated protein 1

Gene names:ABCC1

Standard solution:2400ng/mL