Human Moesin, MSN ELISA Kit

SKU: E4441Hu

Size:96 Tests-1 Kit

Background:Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed: 10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed: 10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed: 12387735, PubMed: 15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed: 9298994, PubMed: 9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (PubMed: 27405666).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:MSN

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.47ng/L

Detection range:200-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Moesin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P26038

MASS(Da):67,820

GeneID:4478

Synonyms:Membrane-organizing extension spike protein;Moesin;MSN

Gene names:MSN

Standard solution:4800ng/L